Caffeine protects against combined paraquat and maneb-induced dopaminergic neuron degeneration
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چکیده
منابع مشابه
Overexpression of superoxide dismutase or glutathione peroxidase protects against the paraquat + maneb-induced Parkinson disease phenotype.
Oxidative stress has been implicated in the pathogenesis of Parkinson disease based on its role in the cascade of biochemical changes that lead to dopaminergic neuronal death. This study analyzed the role of oxidative stress as a mechanism of the dopaminergic neurotoxicity produced by the combined paraquat and maneb model of the Parkinson disease phenotype. Transgenic mice overexpressing either...
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Experimental evidence supporting 1,1'-dimethyl-4,4'-bipyridinium [paraquat (PQ)] as a risk factor for Parkinson's disease (PD) is equivocal. Other agricultural chemicals, including dithiocarbamate fungicides such as manganese ethylenebisdithiocarbamate [maneb (MB)], are widely used in the same geographical regions as paraquat and also impact dopamine systems, suggesting that mixtures may be mor...
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-Synuclein is likely to play a role in neurodegenerative processes, including the degeneration of nigrostriatal dopaminergic neurons that underlies Parkinson’s disease. However, the toxicological properties of -synuclein remain relatively unknown. Here, the relationship between -synuclein expression and neuronal injury was studied in mice exposed to the herbicide paraquat. Paraquat neurotoxicit...
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ژورنال
عنوان ژورنال: Experimental Neurology
سال: 2010
ISSN: 0014-4886
DOI: 10.1016/j.expneurol.2010.02.007